GUT PHARMACOMICROBIOMICS: THE TIP OF AN ICEBERG OF COMPLEX INTERACTIONS BETWEEN DRUGS AND GUT-ASSOCIATED MICROBES

Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbes

Abstract The influence of resident gut microbes on xenobiotic metabolism Figurines has been investigated at different levels throughout the past five decades.However, with the advance in sequencing and pyrotagging technologies, addressing the influence of microbes on xenobiotics had to evolve from assessing direct metabolic effects on toxins and bo

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Tryptophan residue enhances in vitro walnut protein-derived peptides exerting xanthine oxidase inhibition and antioxidant activities

The modulation of xanthine oxidase (XO) activity is critical to the treatment of Alarm Clock hyperuricemia and oxidative stress-related disease.Although the walnut protein hydrolysates had been reported to inhibit XO, their interaction mechanism remained unclear.Herein, the walnut protein-derived peptides were used to evaluate their in vitro XO-inh

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